Cart
sales@molnova.com
SGC2085 HCl
CAS No. 1821908-49-9
SGC2085 HCl( —— )
Catalog No. M17389 CAS No. 1821908-49-9
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 138 | In Stock |
|
| 5MG | 180 | In Stock |
|
| 10MG | 325 | In Stock |
|
| 25MG | 537 | In Stock |
|
| 50MG | 781 | In Stock |
|
| 100MG | 1071 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSGC2085 HCl
-
NoteResearch use only, not for human use.
-
Brief DescriptionSGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs.
-
DescriptionSGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorCoactivator Associated Arginine Methyltransferase 1 (CARM1)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1821908-49-9
-
Formula Weight348.87
-
Molecular FormulaC19H24N2O2·HCl
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(=O)([C@H](C)N)NCc1cc(c(cc1)Oc1cc(cc(c1)C)C)C.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Renato., et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening . J Med Chem. 2016 Jul 28;59(14):6838-47.
molnova catalog
related products
-
SMARCA-BD ligand 1 f...
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunit SMARCA2 and is used for degrading SMARCA2 based on PROTAC.
-
GSK046
GSK046 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively).
-
C646
C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay.
