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XEN-445
CAS No. 1515856-92-4
XEN-445( XEN445 | XEN 445 | XEN-445 )
Catalog No. M17330 CAS No. 1515856-92-4
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
|
| 5MG | 31 | In Stock |
|
| 10MG | 60 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 206 | In Stock |
|
| 100MG | 319 | In Stock |
|
| 200MG | 453 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXEN-445
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NoteResearch use only, not for human use.
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Brief DescriptionXEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
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DescriptionXEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
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In Vitro——
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In Vivo——
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SynonymsXEN445 | XEN 445 | XEN-445
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptorendothelial lipase
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number1515856-92-4
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Formula Weight366.33
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Molecular FormulaC18H17F3N2O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 40 mg/mL. 109.19 mM
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SMILESc1(ccc(c(c1)C(=O)O)N1C[C@H](CC1)OCc1ncccc1)C(F)(F)F
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Chemical Name(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sun S, et al. Bioorg Med Chem. 2013, 21(24), 7724-7734.
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