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Deltarasin
CAS No. 1440898-61-2
Deltarasin( —— )
Catalog No. M17298 CAS No. 1440898-61-2
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
|
| 5MG | 110 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDeltarasin
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NoteResearch use only, not for human use.
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Brief DescriptionDeltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
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DescriptionDeltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
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In VitroIn liver cells, deltarasin inhibits the interaction of RAS with PDEδ with Kd?of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
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In VivoDeltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetAntiviral
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RecptorPDEδ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1440898-61-2
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Formula Weight603.75
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Molecular FormulaC40H37N5O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 42 mg/mL. 69.57 mM
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SMILESC(OC1=CC=C(C=C1)C1=NC2=C(C=CC=C2)N1CC1=CC=CC=C1)[C@H](C1CCNCC1)N1C2=CC=CC=C2N=C1C1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zimmermann G, et al. Nature. 2013, 497(7451), 638-642.
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