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NSC5844
CAS No. 140926-75-6
NSC5844( NSC5844 | NSC-5844 | NSC 5844 | RE640 )
Catalog No. M17281 CAS No. 140926-75-6
NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 28 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 84 | In Stock |
|
| 50MG | 122 | In Stock |
|
| 100MG | 179 | In Stock |
|
| 200MG | 270 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC5844
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NoteResearch use only, not for human use.
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Brief DescriptionNSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
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DescriptionNSC5844, also known as RE640, is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties.
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In VitroNSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively.
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In Vivo——
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SynonymsNSC5844 | NSC-5844 | NSC 5844 | RE640
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorCCR1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number140926-75-6
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Formula Weight383.27
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Molecular FormulaC20H16Cl2N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 1 mg/mL (2.61 mM)
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SMILESc1cc2c(ccnc2cc1Cl)NCCNc1c2ccc(cc2ncc1)Cl
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Chemical NameN,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang H, et al. Biomed PharmacOthers. 2008 Feb;62(2):65-9.
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