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CX-6258 HCl
CAS No. 1353859-00-3
CX-6258 HCl( CX-6258 Hydrochloride | CX 6258 Hydrochloride )
Catalog No. M17253 CAS No. 1353859-00-3
CX-6258 HCl is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 235 | In Stock |
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| 50MG | 368 | In Stock |
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| 100MG | 554 | In Stock |
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| 200MG | 788 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCX-6258 HCl
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NoteResearch use only, not for human use.
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Brief DescriptionCX-6258 HCl is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
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DescriptionCX-6258 HCl is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.
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In VitroWestern Blot Analysis Cell Line:MV-4-11 human AML cells.Concentration:0.1 μM, 1 μM, 10 μM.Incubation Time:2 hours.Result:Caused dose dependent inhibition of the phosphorylation of two pro-survival proteins, Bad and 4E-BP1, at the Pim kinase specific sites S112 and S65 and T37/46, respectively.
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In VivoAnimal Model:Nude mice, MV-4-11 xenograft modelsDosage:50 mg/kg, 100 mg/kg.Administration:Oral administration; once daily; over a period of 21 days.Result:Exhibitd dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI.
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SynonymsCX-6258 Hydrochloride | CX 6258 Hydrochloride
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PathwayOthers
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TargetOther Targets
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RecptorPim1| Pim2| Pim3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1353859-00-3
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Formula Weight498.4
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Molecular FormulaC26H24ClN3O3·HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (20.06 mM)
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SMILESCN1CCCN(CC1)C(=O)c1cccc(c1)c1ccc(o1)/C=C/1\c2c(ccc(c2)Cl)NC1=O.Cl
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Chemical Name(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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