E6446 dihydrochloride( —— )

Catalog No. M17250 CAS No. 1345675-25-3

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	236	In Stock
2MG	123	In Stock
5MG	205	In Stock
10MG	321	In Stock
25MG	619	In Stock
50MG	877	In Stock
100MG	1190	In Stock
200MG	1600	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

E6446 dihydrochloride
Note

Research use only, not for human use.
Brief Description

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
Description

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

TLR
Research Area

Inflammation/Immunology
Indication

——

Chemical Information

CAS Number

1345675-25-3
Formula Weight

522.51
Molecular Formula

C27H37Cl2N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 7.6 mg/mL (14.55 mM)
SMILES

c1(c2ccc(OCCCN3CCCC3)cc2)nc2ccc(OCCCN3CCCC3)cc2o1.Cl.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

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