Cart
sales@molnova.com
CNX-1351
CAS No. 1276105-89-5
CNX-1351( CNX1351 | CNX 1351 | CNX-1351 )
Catalog No. M17234 CAS No. 1276105-89-5
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 92 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 281 | In Stock |
|
| 50MG | 509 | In Stock |
|
| 100MG | 734 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1516 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCNX-1351
-
NoteResearch use only, not for human use.
-
Brief DescriptionCNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
-
DescriptionCNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20 400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
-
In Vitro——
-
In Vivo——
-
SynonymsCNX1351 | CNX 1351 | CNX-1351
-
PathwayOthers
-
TargetOther Targets
-
RecptorPI3Kα
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1276105-89-5
-
Formula Weight573.71
-
Molecular FormulaC30H35N7O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 21.8 mg/mL. 38.00 mM
-
SMILESC1CN(CCN1C(=O)CCC(=O)C=C(C)C)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1
-
Chemical Name1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.
molnova catalog
related products
-
DI-N-OCTYL PHTHALATE
Phthalate ester used as plasticizers and additives. Used in toxicology studies as well as risk assessment studies of food contamination that occurs via migration of phthalates into foodstuffs from food-contact materials (FCM).
-
pTH-Related Protein ...
pTH-Related Protein Splice Isoform 3 (140-173) (human)
-
24-Methylene cycloar...
24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells.
