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ALW-II-41-27
CAS No. 1186206-79-0
ALW-II-41-27( ALW-II-41-27 | ALW II-41-27 | ALWII-41-27 )
Catalog No. M17176 CAS No. 1186206-79-0
ALW-II-41-27, an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 228 | In Stock |
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| 5MG | 162 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 392 | In Stock |
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| 50MG | 538 | In Stock |
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| 100MG | 737 | In Stock |
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| 200MG | 1014 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameALW-II-41-27
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NoteResearch use only, not for human use.
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Brief DescriptionALW-II-41-27, an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.
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DescriptionALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo. ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant, EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors.
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In VitroALW-II-41-27 inhibits Ba/F3 cells transformed with Tel fusions of EphA3, Kit, Fms, KDR, FLT1, FGR, Src, Lyn, Bmx, and Bcr-Abl with an EC50?below 500 nM. ALW-II-41-27 exhibits cross reactivity with Bcr-Abl. ALW-II-41-27 inhibits b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38α, p38β, PDGFRα, PDGFRβ, and Raf1 and many more demonstrating how introduction of the thiophene group can have a tremendous impact on kinase selectivity.
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In Vivo——
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SynonymsALW-II-41-27 | ALW II-41-27 | ALWII-41-27
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorEphrin Receptor
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1186206-79-0
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Formula Weight607.7
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Molecular FormulaC32H32F3N5O2S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 47 mg/mL. 77.34 mM
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SMILESCC1=C(NC(C2=CC(C3=CC=CS3)=CN=C2)=O)C=C(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)C=C1
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Chemical NameN-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-5-(thiophen-2-yl)nicotinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4467-4470.
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