MLN2480( TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480 )

Catalog No. M17143 CAS No. 1096708-71-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MLN2480
Note

Research use only, not for human use.
Brief Description

MLN2480 is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.
Description

TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.
In Vitro

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In Vivo

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Synonyms

TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480
Pathway

TGF-beta/Smad
Target

TGFBR
Recptor

Raf
Research Area

Cancer
Indication

——

CAS Number

1096708-71-2
Formula Weight

506.29
Molecular Formula

C17H12Cl2F3N7O2S
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 98.76 mM;
SMILES

Nc1ncnc(C(=O)N[C@H](C)c2ncc(C(=O)Nc3ncc(Cl)c(C(F)(F)F)c3)s2)c1Cl
Chemical Name

(R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide

1 Elizabeth Grace Carideo Cunniff, et al. Journal of Clinicalal Oncology 31, no. 15_suppl - published online before print.

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