VUF10460( —— )

Catalog No. M17121 CAS No. 1028327-66-3

VUF10460 is a non-imidazole histamine H4 receptor agonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	32	In Stock
5MG	28	In Stock
10MG	47	In Stock
25MG	93	In Stock
50MG	161	In Stock
100MG	251	In Stock
200MG	370	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

VUF10460
Note

Research use only, not for human use.
Brief Description

VUF10460 is a non-imidazole histamine H4 receptor agonist.
Description

VUF10460 is a non-imidazole histamine H4 receptor agonist.
In Vitro

UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor.
In Vivo

HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

H4 receptor
Research Area

Inflammation/Immunology
Indication

——

Chemical Information

CAS Number

1028327-66-3
Formula Weight

269.35
Molecular Formula

C15H19N5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 36 mg/mL 133.66 mM
SMILES

CN1CCN(CC1)c1cc(c2ccccc2)nc(N)n1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Coruzzi G, et al. Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur J Pharmacol. 2011 Nov 1;669(1-3):121-7.

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