BRD4 inhibitor Compound V( —— )

Catalog No. M17061 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BRD4 inhibitor Compound V
Note

Research use only, not for human use.
Brief Description

BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
Description

BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively; demonstrates reduction of c-Myc expression, inhibition of NF-κB signaling, and suppression of IL-8 production through potential synergistic inhibition of BRD4(1) and p38α.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

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Indication

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CAS Number

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Formula Weight

442.542
Molecular Formula

C26H27FN6
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-(3,5-dimethylphenyl)-4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1Himidazol-5-yl)pyrimidin-2-amine

1. Anand Divakaran, et al. J. Med. Chem., 2018, 61 (20), pp 9316-9334.

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