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Pomstafib-2
CAS No. ——
Pomstafib-2( Pomstafib 2 )
Catalog No. M17027 CAS No. ——
The pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePomstafib-2
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NoteResearch use only, not for human use.
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Brief DescriptionThe pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.
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DescriptionThe pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM; decreases the phosphorylation at STAT5b Tyr699 with IC50 of 1.5 uM in STAT5b-GFP-transfected K562 cells in human leukaemia cells and induces apoptosis in a STAT5-dependent manner; shows high selectivity for STAT5b over STAT5a.
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In Vitro——
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In Vivo——
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SynonymsPomstafib 2
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight1101.042
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Molecular FormulaC52H66N2O20P2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name((((4-((2-(4-((4-phenoxyphenyl)carbamoyl)phenoxy)acetamido)methyl)-1,2-phenylene)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.
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