cIAP1 E3 ligase inhibitor D19-14( cIAP1 inhibitor D19-14 )

Catalog No. M17008 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

cIAP1 E3 ligase inhibitor D19-14
Note

Research use only, not for human use.
Brief Description

cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro.
Description

cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro; D19-14 is more potent in inhibiting the proliferation of cancer cells than D19, D19-14 exhibits acceptable pharmacokinetics properties in vivo, effectively decreases the levels of c-MYC protein in tumors in cancer xenograft model.
In Vitro

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In Vivo

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Synonyms

cIAP1 inhibitor D19-14
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

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Indication

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CAS Number

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Formula Weight

385.456
Molecular Formula

C18H15N3O3S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(E)-2-((2-(5,6-dimethoxybenzo[d]thiazol-2-yl)hydrazono)methyl)benzo[b]thiophen-3-ol

1. Li H, et al. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201807711.

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