MKK7-COV-13

Research use only, not for human use.

MKK7-COV-13 (MKK7 Covalen inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM.

MKK7-COV-13 (MKK7 Covalen inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM); shows EC50 of 0.3-1.0 uM for reduction of p-JNK in HEK293 cell line, without effect on p-ERK levels at 10 uM; displays remarkable selectivity against a kinome panel of 76 kinases; inhibits the CD86+ response in primary mouse B cells in response to LPS stimulation.

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MKK7 Covalen inhibitor 13

MAPK/ERK Signaling

MEK

MEK

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342.196

C16H12BrN3O

>98% (HPLC)

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N-(3-(6-bromo-1H-indazol-3-yl)phenyl)acrylamide

(-20℃)

With Ice Pack

≥ 2 years