JL5( BMP receptor inhibitor JL5 )

Catalog No. M16992 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

JL5
Note

Research use only, not for human use.
Brief Description

JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively.
Description

JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively; shows much weaker acitivity against BMPR2, ALK5/TGFβR1 and TGFβR2 with IC50 of 8,510, 440 and 40 nM; shows a greater volume of distribution and suppresses the expression of Id1 and pTak1 in tumor xenografts, induces tumor cell death and tumor regression in xenograft mouse models without immune cells and humanized with adoptively transferred human immune cells.
In Vitro

——
In Vivo

——
Synonyms

BMP receptor inhibitor JL5
Pathway

TGF-beta/Smad
Target

TGFBR
Recptor

TGFBR
Research Area

——
Indication

——

CAS Number

——
Formula Weight

449.558
Molecular Formula

C28H27N5O
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

4-(3-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)propyl)morpholine

1. Newman JH, et al. Oncogene. 2018 Apr 6. doi: 10.1038/s41388-018-0156-9.

Calculator

molnova catalog