NWL-117( NWL117 | NWL 117 )

Catalog No. M16926 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NWL-117
Note

Research use only, not for human use.
Brief Description

A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
Description

A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM; shows weak activity against other Capase subutypes; inhibits Caspase-6 in Caspase-6-transfected HCT116 cells with IC50 of 4.82 uM; inhibits serum deprivation-induced Caspase-6 activity and prevents amyloid precursor protein-mediated neurite degeneration in human primary CNS neurons; BBB penetrant.
In Vitro

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In Vivo

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Synonyms

NWL117 | NWL 117
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase
Research Area

——
Indication

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CAS Number

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Formula Weight

654.732
Molecular Formula

C29H42N4O11S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)[C@@H](/C=C/S(=O)(C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Chemical Name

(5S,8S,11S,14R)-11-((S)-sec-butyl)-8-(2-carboxyethyl)-5-isopropyl-14-((E)-2-(methylsulfonyl)vinyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid

1. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22.

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