CM11( CM-11 | CM 11 )

Catalog No. M16922 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

CM11
Note

Research use only, not for human use.
Brief Description

A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation; induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
Description

A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation; induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response; a novel chemical probe for selective VHL knockdown.
In Vitro

——
In Vivo

——
Synonyms

CM-11 | CM 11
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

——
Formula Weight

1179.456
Molecular Formula

C58H82N8O14S2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O
Chemical Name

N1,N20-bis((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide

1. Maniaci C, et al. Nat Commun. 2017 Oct 10;8(1):830.

Calculator

molnova catalog