Isothiafludine( NZ-4 )

Catalog No. M16861 CAS No. 960527-22-4

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HNMR

HPLC

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Product Name

Isothiafludine
Note

Research use only, not for human use.
Brief Description

Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM.
Description

Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM; shows activity against the replication of various drug-resistant HBV mutants, including 3TC/ETV-dual-resistant and ADV-resistant HBV mutants; concentration-dependently reduces the encapsidated HBV pgRNA, resulting in the assembly of replication-deficient capsids in HepG2.2.15 cells; inhibits DHBV DNA replication in the DHBV-infected ducks after oral administration.HBV Infection Phase 1 Clinical.
In Vitro

——
In Vivo

Animal Model:DHBV-infected duck modelDosage:25-100 mg/kg Administration:p.o., for 15 days Result:Inhibited DHBV DNA in the sera on day 15.
Synonyms

NZ-4
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

Infection
Indication

HBV Infection

CAS Number

960527-22-4
Formula Weight

375.48
Molecular Formula

C18H18FN3OS2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
Chemical Name

N-[(4-Fluorophenyl)methyl]-5-(2-methylpropyl)[2,2'-bithiazole]-4-carboxamide

1. Yang L, et al. Acta Pharmacol Sin. 2014 Mar;35(3):410-8. 2. Yang L, et al. Antiviral Res. 2016 Jan;125:25-33.

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