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MLE-4901
CAS No. 941690-55-7
MLE-4901( MLE4901 | AZD-2624 | AZD2624 | Pavinetant )
Catalog No. M16736 CAS No. 941690-55-7
A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 173 | In Stock |
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| 2MG | 101 | In Stock |
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| 5MG | 169 | In Stock |
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| 10MG | 258 | In Stock |
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| 25MG | 345 | In Stock |
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| 50MG | 423 | In Stock |
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| 100MG | 609 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMLE-4901
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
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DescriptionA potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia; demonstrates drug-like properties with low metabolic turnover rate in vitro and moderate human plasma protein binding.Schizophrenia Phase 2 Discontinued.
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In VitroPavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia. Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6.
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In Vivo——
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SynonymsMLE4901 | AZD-2624 | AZD2624 | Pavinetant
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNeurokinin Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number941690-55-7
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Formula Weight459.56
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Molecular FormulaC26H25N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 50 mg/mL 108.80 mM; H2O : < 0.1 mg/mL
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SMILESO=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
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Chemical Name(S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9.
2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893.
3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
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