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Home - Products - GPCR/G Protein - Neurokinin Receptor - MLE-4901

MLE-4901

CAS No. 941690-55-7

MLE-4901( MLE4901 | AZD-2624 | AZD2624 | Pavinetant )

Catalog No. M16736 CAS No. 941690-55-7

A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 173 In Stock
2MG 101 In Stock
5MG 169 In Stock
10MG 258 In Stock
25MG 345 In Stock
50MG 423 In Stock
100MG 609 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    MLE-4901
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
  • Description
    A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia; demonstrates drug-like properties with low metabolic turnover rate in vitro and moderate human plasma protein binding.Schizophrenia Phase 2 Discontinued.
  • In Vitro
    Pavinetant (AZD2624) is a potent and selective NK3 receptor antagonist which is developed for the treatment of schizophrenia. Pavinetant exhibits an inhibitory effect on microsomal CYP3A4/5 activities with apparent IC50 values of 7.1 and 19.8 μM for midazolam and testosterone assays, respectively. No time-dependent inactivation of CYP3A4/5 activity by Pavinetant is observed. Pavinetant demonstrates weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6.
  • In Vivo
    ——
  • Synonyms
    MLE4901 | AZD-2624 | AZD2624 | Pavinetant
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    Neurokinin Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    941690-55-7
  • Formula Weight
    459.56
  • Molecular Formula
    C26H25N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL 108.80 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
  • Chemical Name
    (S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9. 2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893. 3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
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