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TG-101348
CAS No. 936091-26-8
TG-101348( Fedratinib | SAR 302503 | TG101348 | TG 101348 )
Catalog No. M16699 CAS No. 936091-26-8
TG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 57 | In Stock |
|
| 50MG | 104 | In Stock |
|
| 100MG | 122 | In Stock |
|
| 200MG | 205 | In Stock |
|
| 500MG | 447 | In Stock |
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| 1G | 592 | In Stock |
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Biological Information
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Product NameTG-101348
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NoteResearch use only, not for human use.
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Brief DescriptionTG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F.
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DescriptionTG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F; also inhibits FLT3 (IC50=15 nM) and RET (IC50=48 nM) kinases, weakly inhibits JAK3 (IC50=168 nM), >35-fold selectivity over JAK1/3 and Tyk2; shows therapeutic efficacy in a murine model of myeloproliferative disease induced by the JAK2V617F mutation; also potently inhibits BRD4 with Kd of 168 nM.Bone Cancer Phase 3 Clinical.
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In Vitro——
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In VivoAnimal Model:C57Bl/6 mice induced by the JAK2V617F mutation Dosage:60 mg/kg, 120 mg/kg Administration:Oral gavage; twice daily; for 42 days Result:Showed a statistically significant reduction in hematocrit and leukocyte count, a dose-dependent reduction/elimination of extramedullary hematopoiesis.
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SynonymsFedratinib | SAR 302503 | TG101348 | TG 101348
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PathwayAngiogenesis
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TargetJAK
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RecptorFLT3|JAK2|JAK2(V617F)|RET
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Research AreaCancer
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IndicationBone Cancer
Chemical Information
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CAS Number936091-26-8
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Formula Weight524.6782
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Molecular FormulaC27H36N6O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 42 mg/mL
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SMILESO=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCN4CCCC4)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O
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Chemical NameBenzenesulfonamide, N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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PF-06651600
PF-06651600 is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2; inhibits Th1 and Th17 cell differentiation and function, reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models; selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFα and IL-1β production in IL-27-primed macrophages.Rheumatoid ArthritisPhase 2 Clinical
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Decernotinib
Decernotinib (VX-509, VRT-831509) is a potent, selective, orally available JAK3 inhibitor with Ki of 2.5 nM and cellular IC50 of 50-170 nM.
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Iridin
Iridin is major active ingredient of Iris dichotoma which could be used as the drug for pain, inflammation treatment.
