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PF 03716556
CAS No. 928774-43-0
PF 03716556( —— )
Catalog No. M16652 CAS No. 928774-43-0
PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 84 | In Stock |
|
| 25MG | 168 | In Stock |
|
| 50MG | 313 | In Stock |
|
| 100MG | 495 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF 03716556
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NoteResearch use only, not for human use.
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Brief DescriptionPF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively.
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DescriptionPF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg Administration:Intraduodenal administration; once Result:Inhibited gastric acid secretion in a dose-dependent manner.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorH+/K+-ATPase
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number928774-43-0
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Formula Weight394.48
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Molecular FormulaC22H26N4O3
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Purity>98% (HPLC)
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SolubilityEthanol: 79 mg/mL (200.26 mM); DMSO: 79 mg/mL (200.26 mM)
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SMILESCC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mori, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.
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