VRX-0466617( VRX 0466617 | VRX0466617 )

Catalog No. M16639 CAS No. 926906-64-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VRX-0466617
Note

Research use only, not for human use.
Brief Description

A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM).
Description

A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM); inhibits the phosphorylation of Chk2 Ser(19) and Ser(33-35), but not of Chk2 Thr(68), prevents the IR-induced Chk2-dependent degradation of Hdmx and attenuates IR-induced apoptosis.
In Vitro

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In Vivo

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Synonyms

VRX 0466617 | VRX0466617
Pathway

Angiogenesis
Target

Chk
Recptor

Chk
Research Area

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Indication

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CAS Number

926906-64-1
Formula Weight

462.366
Molecular Formula

C19H20BrN5O2S
Purity

>98% (HPLC)
Solubility

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SMILES

N/C(C1=C(NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)SNC1=O)=N\C(C)CO
Chemical Name

5-[4-(4-Bromoanilino)anilino]-N'-(1-hydroxypropan-2-yl)-3-oxo-1,2-thiazole-4-carboximidamide

1. Carlessi L, et al. Mol Cancer Ther. 2007 Mar; 6(3):935-44. 2. Carlessi L, et al. Biochim Biophys Acta. 2010 Oct;1803(10):1213-23.

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