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VRX-0466617
CAS No. 926906-64-1
VRX-0466617( VRX 0466617 | VRX0466617 )
Catalog No. M16639 CAS No. 926906-64-1
A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVRX-0466617
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM).
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DescriptionA potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM; shows no inhibitory effect on Chk1 (>100 uM); inhibits the phosphorylation of Chk2 Ser(19) and Ser(33-35), but not of Chk2 Thr(68), prevents the IR-induced Chk2-dependent degradation of Hdmx and attenuates IR-induced apoptosis.
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In Vitro——
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In Vivo——
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SynonymsVRX 0466617 | VRX0466617
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number926906-64-1
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Formula Weight462.366
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Molecular FormulaC19H20BrN5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESN/C(C1=C(NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)SNC1=O)=N\C(C)CO
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Chemical Name5-[4-(4-Bromoanilino)anilino]-N'-(1-hydroxypropan-2-yl)-3-oxo-1,2-thiazole-4-carboximidamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
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PHI-101
PHI-101 is an orally available and selective checkpoint kinase 2 (Chk2) inhibitor for the study of refractory acute myelogenous leukemia (AML) and ovarian cancer.
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PF-00477736
PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM).
