Cart
sales@molnova.com
KU-60019 (b)
CAS No. 925701-49-1
KU-60019 (b)( KU60019 | KU 60019 | KU-60019. )
Catalog No. M16634 CAS No. 925701-49-1
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
|
| 10MG | 91 | In Stock |
|
| 25MG | 158 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameKU-60019 (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionKU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays.
-
DescriptionKU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.
-
In Vitro——
-
In Vivo——
-
SynonymsKU60019 | KU 60019 | KU-60019.
-
PathwayCell Cycle/DNA Damage
-
TargetATM/ATR
-
RecptorATM
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number925701-49-1
-
Formula Weight547.67
-
Molecular FormulaC30H33N3O5S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 18 mg/mL warmed (32.86 mM)
-
SMILESO=C(NC1=CC(CC2=C(C(C3=CC(C=C(N4CCOCC4)O3)=O)=CC=C2)S5)=C5C=C1)CN6C[C@H](C)O[C@H](C)C6
-
Chemical Name2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide.
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Golding SE, et al. Mol Y Ther, 2009, 8(10), 2894-2902.
molnova catalog
related products
-
AZD-0156
AZD-0156 (AZD0156, AZD 0156)?is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors,Phase 1 Clinical
-
KU-60019
KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.
-
Ro 90-7501
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.
