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USP8-IN-22e
CAS No. 924296-19-5
USP8-IN-22e( —— )
Catalog No. M16623 CAS No. 924296-19-5
A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 173 | In Stock |
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| 5MG | 158 | In Stock |
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| 10MG | 245 | In Stock |
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| 25MG | 493 | In Stock |
|
| 50MG | 705 | In Stock |
|
| 100MG | 1023 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUSP8-IN-22e
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.
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DescriptionA potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM; shows no inhibitory activity for USP7 (IC50>100 uM).
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In VitroDUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5μM.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number924296-19-5
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Formula Weight275.2649
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Molecular FormulaC15H9N5O
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Purity>98% (HPLC)
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SolubilityDMSO: 9.06 mg/mL
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SMILESCCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N
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Chemical Name9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.
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