Cart
sales@molnova.com
USP8-IN-22e
CAS No. 924296-19-5
USP8-IN-22e( —— )
Catalog No. M16623 CAS No. 924296-19-5
A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 173 | In Stock |
|
| 5MG | 158 | In Stock |
|
| 10MG | 245 | In Stock |
|
| 25MG | 493 | In Stock |
|
| 50MG | 705 | In Stock |
|
| 100MG | 1023 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameUSP8-IN-22e
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM.
-
DescriptionA potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM; shows no inhibitory activity for USP7 (IC50>100 uM).
-
In VitroDUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5μM.
-
In Vivo——
-
Synonyms——
-
PathwayProteasome/Ubiquitin
-
TargetDUB
-
RecptorDUB
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number924296-19-5
-
Formula Weight275.2649
-
Molecular FormulaC15H9N5O
-
Purity>98% (HPLC)
-
SolubilityDMSO: 9.06 mg/mL
-
SMILESCCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N
-
Chemical Name9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-(ethoxyimino)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.
molnova catalog
related products
-
GSK2643943A
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
-
STD1T
STD1T (USP2a inhibitor STD1T) is a hit-to-lead, small-molecule inhibitor of USP2a with IC50 of 3.3 uM in Ub-AMC assays.
-
USP30 inhibitor 11
USP30 inhibitor 11 (USP30-IN-11) is a selective USP30 inhibitor (IC50: 0.01 μΜ) that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.
