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NSC260594
CAS No. 906718-66-9
NSC260594( NSC 260594 )
Catalog No. M16515 CAS No. 906718-66-9
NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNSC260594
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NoteResearch use only, not for human use.
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Brief DescriptionNSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging.
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DescriptionNSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global packaging signal region (psi or ψ); specifically blocks HIV-1 RNA encapsidation, binds to HIV-1 gRNA and exhibits potent antiviral activity; NSC260594 also is a small molecule inhibitor of the Escherichia coli condensin MukBEF, affects MukB directly.
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In Vitro——
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In Vivo——
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SynonymsNSC 260594
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number906718-66-9
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Formula Weight504.55
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Molecular FormulaC29H24N6O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 3.33 mg/mL
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SMILESCN1C=CC(=NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)N=C4C=CN(C5=C4C=C(C=C5)[N+](=O)[O-])C)C=C1
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Chemical Name4-[(1-methyl-6-nitroquinolin-4-ylidene)amino]-N-[4-[(1-methylpyridin-4-ylidene)amino]phenyl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ingemarsdotter CK, et al. Retrovirology. 2018 Mar 14;15(1):25.
2. Zhao H, et al. ACS Infect Dis. 2018 Oct 22. doi: 10.1021/acsinfecdis.8b00222.
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