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BRPF1-IN-3
CAS No. 901245-65-6
BRPF1-IN-3( GSK-5959 | GSK 5959 | GSK5959. )
Catalog No. M16481 CAS No. 901245-65-6
BRPF1-IN-3 is a potent, selective, membrane permeable BRPF1 bromodomain inhibitor with pIC50 of 7.1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 151 | In Stock |
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| 50MG | 245 | In Stock |
|
| 100MG | 365 | In Stock |
|
| 200MG | 533 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBRPF1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionBRPF1-IN-3 is a potent, selective, membrane permeable BRPF1 bromodomain inhibitor with pIC50 of 7.1.
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DescriptionBRPF1-IN-3 is a potent, selective, membrane permeable BRPF1 bromodomain inhibitor with pIC50 of 7.1; shows 100- and >1000-fold selectivity over BRPF2 and BRPF3, respectively; exhibits an IC50 of 0.98 uM in cellular protein interaction assay (displacement of NanoLuc-tagged BRPF1 bromodomain from Halo-tagged histone H3.3).
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In VitroGSK-5959 (3a) also displays selectivity over the closely related family members, BRPF2 (100-fold) and BRPF3 (>1000-fold).GSK-5959 (3a) exhibits an EC50 = 0.98 μM) in cellular NanoBRET assay.GSK-5959 has no effect on TRIM24 SUMOylation.
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In Vivo——
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SynonymsGSK-5959 | GSK 5959 | GSK5959.
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBRPF1
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number901245-65-6
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Formula Weight394.475
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Molecular FormulaC22H26N4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
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Chemical NameN-(1,3-dimethyl-2-oxo-6-(piperidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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