PFI-4( PFI-4 | PFI 4 | PFI4 )

Catalog No. M16470 CAS No. 900305-37-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PFI-4
Note

Research use only, not for human use.
Brief Description

A potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3.
Description

A potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3; exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
In Vitro

PFI-4 (1.25 μM; 7 or 11 days) inhibits differentiation of human osteoclasts. Cell Viability Assay Cell Line:Osteoclasts Concentration:1.25 μM Incubation Time:7 or 11 days Result:Significantly reduces MMP9 secretion in osteoclasts.
In Vivo

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Synonyms

PFI-4 | PFI 4 | PFI4
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRPF1|BRPF2|BRPF3
Research Area

Other Indications
Indication

——

CAS Number

900305-37-5
Formula Weight

380.4402
Molecular Formula

C21H24N4O3
Purity

>98% (HPLC)
Solubility

DMSO: 26 mg/mL
SMILES

O=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
Chemical Name

Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-

1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.

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