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DSM 74

CAS No. 898743-92-5

DSM 74( DSM74 )

Catalog No. M16464 CAS No. 898743-92-5

A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DSM 74
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
  • Description
    A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity; shows good plasma exposure in mice and is equally potent against PfDHODH and PbDHODH; suppresses growth of P. berghei in mice after oral administration.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DSM74
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    898743-92-5
  • Formula Weight
    293.253
  • Molecular Formula
    C13H10F3N5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(C1=CC=C(NC2=CC(C)=NC3=NC=NN23)C=C1)(F)F
  • Chemical Name
    5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. 2. Gujjar R, et al. J Med Chem. 2009 Apr 9;52(7):1864-72. 3. Lee JJ, et al. urr Microbiol. 2014 Sep;69(3):286-91.
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