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VX-11e
CAS No. 896720-20-0
VX-11e( VX 11e )
Catalog No. M16451 CAS No. 896720-20-0
A potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 81 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 214 | In Stock |
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| 50MG | 340 | In Stock |
|
| 100MG | 527 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVX-11e
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.
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DescriptionA potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM; shows >200-fold selectivity over GSK3, Aurora A, CDK2, FLT3, etc; significantly inhibits CKAP2 overexpression-induced cell proliferation, migration and invasion in SiHa cells.
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In Vitro——
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In Vivo——
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SynonymsVX 11e
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorAuroraA|CDK2|ERK2|FLT3|GSK-3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number896720-20-0
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Formula Weight500.3523
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Molecular FormulaC24H20Cl2FN5O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=CC(C2=NC(NC3=CC=C(F)C=C3Cl)=NC=C2C)=CN1)N[C@@H](C4=CC=CC(Cl)=C4)CO
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Chemical Name1H-Pyrrole-2-carboxamide, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Aronov AM, et al. J Med Chem. 2009 Oct 22;52(20):6362-8.
2. Krepler C, et al. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.
3. Guo QS, et al. Sci Rep. 2017 May 18;7(1):2117.
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