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BMH-21
CAS No. 896705-16-1
BMH-21( BMH21 )
Catalog No. M16450 CAS No. 896705-16-1
BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 33 | In Stock |
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| 10MG | 53 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 154 | In Stock |
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| 100MG | 268 | In Stock |
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| 200MG | 402 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBMH-21
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NoteResearch use only, not for human use.
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Brief DescriptionBMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM.
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DescriptionBMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription; inhibits the expression of 47S rRNA transcript with IC50 of 60 nM, blocks transcription of the rRNA precursor without affecting rRNA maturation, and causes segregation of nucleolar proteins; causes proteasome-mediated degradation of RPA194 (Pol I catalytic subunit); activates p53 and inhibits TP53 null and mutant cell lines with GI50 of 110 and 205 nM, respectively.
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In VitroBMH-21 binds ribosomal DNA and inhibits Pol I transcription.BMH-21 inhibits RNA polymerase I independent of DNA damage response.BMH-21 intercalates into double strand (ds) DNA and has binding preference towards GC-rich DNA sequences.BMH-21 (1 μM; 3 hours) acts in a DNA damage independent manner to activate nucleolar stress and RPA194 degradation.Cell Viability AssayCell Line:U2OS cells Concentration:0 μM, 0.1 μM , 1 μM, 10 μM Incubation Time:48 hoursResult:Decreased the viability of cells at concentrations that activated the DNA damage response.Western Blot AnalysisCell Line:A375 cellsConcentration:1 μM Incubation Time:3 hours Result:Degraded RPA194 with blocked ATM and DNA-PKcs activity.
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In VivoBMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo. Animal Model:6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft Dosage:50 mg/kg Administration:Intraperitoneal injection, daily, for 6 days Result:Significantly inhibited HCT116 colon cancer tumor growth.
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SynonymsBMH21
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorRNApolymeraseI
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number896705-16-1
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Formula Weight360.4091
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Molecular FormulaC21H20N4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=CC=CN2C1=NC3C=C(C=CC=C4)C4=CC3C2=O)NCCN(C)C
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Chemical Name12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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NSAH?
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.A unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affinity, inhibition, and cell toxicity assays.?NSAH binds to hRRM1 with an apparent dissociation constant of 37 μM, and steady-state kinetics reveal a competitive mode of inhibition.?
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Dibenz[a,h]anthracen...
Dibenz[a,h]anthracene has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.
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Proflavine Hemisulfa...
Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
