DC_05( DC-05 )

Catalog No. M16429 CAS No. 890643-16-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DC_05
Note

Research use only, not for human use.
Brief Description

DC_05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM.
Description

DC_05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM, displays 3.6-fold selectivity over PRMT1 and >15-fold over DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9.
In Vitro

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively. DC-05 shows less potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM). DC-05 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h.
In Vivo

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Synonyms

DC-05
Pathway

Chromatin/Epigenetic
Target

DNMT
Recptor

DNMT
Research Area

Cancer
Indication

——

CAS Number

890643-16-0
Formula Weight

383.4855
Molecular Formula

C25H25N3O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

OC(CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CNCCC4=CNC5=C4C=CC=C5
Chemical Name

9H-Carbazole-9-ethanol, α-[[[2-(1H-indol-3-yl)ethyl]amino]methyl]-

1. Chen S, et al. J Med Chem. 2014 Nov 13;57(21):9028-41.

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