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Fosinopril sodium
CAS No. 88889-14-9
Fosinopril sodium( SQ 28,555 )
Catalog No. M16421 CAS No. 88889-14-9
Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 31 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 59 | In Stock |
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| 50MG | 102 | In Stock |
|
| 100MG | 129 | In Stock |
|
| 200MG | 194 | In Stock |
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| 500MG | 326 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFosinopril sodium
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NoteResearch use only, not for human use.
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Brief DescriptionFosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor.
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DescriptionFosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.(In Vitro):Fosinopril (0, 1, 10, 33, 100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2.Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2.Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with a Ki value of 1.675 μM.(In Vivo):Fosinopril (orally; 4.67 mg/kg; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and against cardiac dysfunction and structural alteration.Fosinopril (orally; 4.67 mg/kg; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model.
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In VitroFosinopril (0, 1, 10, 33, 100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2.Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2.Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with a Ki value of 1.675 μM.
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In VivoFosinopril (orally; 4.67 mg/kg; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and against cardiac dysfunction and structural alteration.Fosinopril (orally; 4.67 mg/kg; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model. Animal Model:HF post-acute myocardial infarction (AMI) rat model (SPF-grade Sprague-Dawley (SD) rats, 265 ± 15 g) Dosage:4.67 mg/kg Administration:p.o.; 4 weeks Result:Against cardiac dysfunction and structural alteration and suppressed apoptosis.
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SynonymsSQ 28,555
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PathwayEndocrinology/Hormones
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TargetRAAS
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RecptorACE
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number88889-14-9
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Formula Weight586.65
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Molecular FormulaC30H45NO7P·Na
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Purity>98% (HPLC)
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SolubilityEthanol: 4 mg/mL (6.83 mM); Water: 117 mg/mL (199.78 mM)
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SMILESCCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)[O-])C3CCCCC3.[Na+]
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Chemical Namesodium;(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sharma S, et al. Fosinopril Hemodynamics Study Group. Am J Ther. 1999 Jul;6(4):181-9.
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