c-FMS-IN-8( —— )

Catalog No. M16411 CAS No. 885704-21-2

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Datasheet

HNMR

HPLC

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Product Name

c-FMS-IN-8
Note

Research use only, not for human use.
Brief Description

c-FMS-IN-8 is a potent, selective c-FMS kinase inhibitor with IC50 of 0.8 nM, shows activity in collagen-induced model of arthritis in mice.
Description

c-FMS-IN-8 is a potent, selective c-FMS kinase inhibitor with IC50 of 0.8 nM, shows activity in collagen-induced model of arthritis in mice.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Tyrosine Kinase
Target

CSF1R
Recptor

CSF1R
Research Area

Inflammation/Immunology
Indication

——

CAS Number

885704-21-2
Formula Weight

406.5239
Molecular Formula

C23H30N6O
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

CC1CCN(CC1)C2=C(C=CC(=C2)N3CCN(CC3)C)NC(=O)C4=CC(=CN4)C#N
Chemical Name

1H-Pyrrole-2-carboxamide, 4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-

1. Illig CR, et al. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8. 2. Meegalla SK, et al. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3632-7.

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