Cart
sales@molnova.com
Tozadenant
CAS No. 870070-55-6
Tozadenant( SYN-115 | SYN115 | SYN 115 )
Catalog No. M16320 CAS No. 870070-55-6
A potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 39 | In Stock |
|
| 5MG | 35 | In Stock |
|
| 10MG | 59 | In Stock |
|
| 25MG | 109 | In Stock |
|
| 50MG | 187 | In Stock |
|
| 100MG | 269 | In Stock |
|
| 200MG | 386 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTozadenant
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.
-
DescriptionA potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.Parkinson's Disease Phase 3 Discontinued(In Vivo):18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.
-
In Vitro——
-
In Vivo18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.
-
SynonymsSYN-115 | SYN115 | SYN 115
-
PathwayGPCR/G Protein
-
TargetAdenosine Receptor
-
RecptorAdenosine Receptor
-
Research AreaNeurological Disease
-
IndicationParkinson Disease
Chemical Information
-
CAS Number870070-55-6
-
Formula Weight406.4991
-
Molecular FormulaC19H26N4O4S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(N1CCC(C)(O)CC1)NC2=NC3=C(OC)C=CC(N4CCOCC4)=C3S2
-
Chemical Name1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Barret O, et al. J Nucl Med. 2014 Oct;55(10):1712-8.
2. Black KJ, et al. J Neurosci. 2010 Dec 1;30(48):16284-92.
molnova catalog
related products
-
2-Cl-IB-MECA
2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
-
Sonedenoson
Sonedenoson (MRE0094) is an adenosine A(2A) receptor agonist and potential inhibitor potentially targeting SARS-CoV-2 coronavirus 2;-O-ribose methyltransferase, and may be used in the study of diabetic foot ulcers.
-
ANR 94
ANR94 is a potent, selective antagonist of the adenosine A2A receptor (AA2AR), exhibiting a K_i value of 46 nM for the human AA2AR (hAA2AR).
