Tozadenant( SYN-115 | SYN115 | SYN 115 )

Catalog No. M16320 CAS No. 870070-55-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Tozadenant
Note

Research use only, not for human use.
Brief Description

A potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.
Description

A potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.Parkinson's Disease Phase 3 Discontinued(In Vivo):18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.
In Vitro

——
In Vivo

18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.
Synonyms

SYN-115 | SYN115 | SYN 115
Pathway

GPCR/G Protein
Target

Adenosine Receptor
Recptor

Adenosine Receptor
Research Area

Neurological Disease
Indication

Parkinson Disease

CAS Number

870070-55-6
Formula Weight

406.4991
Molecular Formula

C19H26N4O4S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(N1CCC(C)(O)CC1)NC2=NC3=C(OC)C=CC(N4CCOCC4)=C3S2
Chemical Name

1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-

1. Barret O, et al. J Nucl Med. 2014 Oct;55(10):1712-8. 2. Black KJ, et al. J Neurosci. 2010 Dec 1;30(48):16284-92.

Calculator

molnova catalog