AL-9( HCV inhibitor AL-9 )

Catalog No. M16312 CAS No. 869218-90-6

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Datasheet

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HPLC

MSDS

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Product Name

AL-9
Note

Research use only, not for human use.
Brief Description

AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a.
Description

AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM; inhibits HCV across different genotypes with activity in the sub-micromolar to low micromolar range in the absence of significant cytotoxic effects; inhibits PI4KIIIα also in living cells, while not appreciably affecting the activity of PI4KIIIβ, does not affect the level of PI4P in the Golgi membrane.
In Vitro

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In Vivo

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Synonyms

HCV inhibitor AL-9
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

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Indication

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CAS Number

869218-90-6
Formula Weight

402.454
Molecular Formula

C23H22N4O3
Purity

>98% (HPLC)
Solubility

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SMILES

OCC1=CC=C(C2=CC3=C(NC4=CC=C(N5CCOCC5)C=C4)N=CN=C3C=C2)O1
Chemical Name

(5-(4-((4-morpholinophenyl)amino)quinazolin-6-yl)furan-2-yl)methanol

1. Bianco A, et al. PLoS Pathog. 2012;8(3):e1002576. 2. MacLeod AM, et al. ACS Med Chem Lett. 2013 May 8;4(7):585-9.

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