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NEDD8 inhibitor M22
CAS No. 864420-54-2
NEDD8 inhibitor M22( —— )
Catalog No. M16270 CAS No. 864420-54-2
NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 205 | Get Quote |
|
| 10MG | 305 | Get Quote |
|
| 25MG | 518 | Get Quote |
|
| 50MG | 743 | Get Quote |
|
| 100MG | 1017 | Get Quote |
|
| 500MG | 2061 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNEDD8 inhibitor M22
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NoteResearch use only, not for human use.
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Brief DescriptionNEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.
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DescriptionNEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor; inhibit A549 cell proliferation completely at 30 uM (GI50=5.5 uM and GI90=19.3 uM); produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in zebrafish model; exhibts different binding mode compared with MLN4924.
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In VitroM22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells.M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 μM (GI50=5.5 μM, GI90=19.3 μM).M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line. Cell Viability Assay Cell Line:A549 cells Concentration:0.37, 1.11, 3.33, 10, 30, 90 μM Incubation Time:24 hours Result:Inhibited formations of Uba3-NEDD8 and Ubc12-NEDD8.Resulted in a corresponding decrease in the abundance of Cullins-NEDD8.
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In VivoM22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts.M22 (0.36-90 μM) has low acute toxicity in zebrafish model.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetE1
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RecptorE1
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Research Area——
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Indication——
Chemical Information
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CAS Number864420-54-2
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Formula Weight363.326
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Molecular FormulaC20H24Cl2N2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (688.10 mM)
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SMILES——
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Chemical Name1-benzyl-N-(2,4-dichlorophenethyl)piperidin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu P, et al. ACS Chem Biol. 2016 Jul 15;11(7):1901-7.
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