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A-740003
CAS No. 861393-28-4
A-740003( A 740003 | A740003 )
Catalog No. M16238 CAS No. 861393-28-4
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 32 | In Stock |
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| 10MG | 50 | In Stock |
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| 50MG | 67 | In Stock |
|
| 100MG | 106 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameA-740003
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NoteResearch use only, not for human use.
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Brief DescriptionA-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively.
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DescriptionA-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively; showed weak or no activity for other P2 receptors (IC50>10 uM); potently blocks agonist-evoked IL-1β release (IC50=156 nM) and pore formation (IC50=92 nM) in differentiated human THP-1 cells; produces dose-dependent antinociception in a spinal nerve ligation model (ED50=19 mg/kg i.p.) in the rat.Pain Discontinued.
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In Vitro——
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In Vivo——
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SynonymsA 740003 | A740003
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PathwayMembrane Transporter/Ion Channel
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TargetP2X Receptor
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RecptorP2X7(Human)|ratP2X7receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number861393-28-4
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Formula Weight474.5548
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Molecular FormulaC26H30N6O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC(/N=C(NC#N)\NC1=C2C=CC=NC2=CC=C1)C(C)(C)C)CC3=CC=C(OC)C(OC)=C3
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Chemical NameBenzeneacetamide, N-[1-[[(cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Honore P, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85.
2. Morytko MJ, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2093-6.
3. King BF. Br J Pharmacol. 2007 Jul;151(5):565-7.
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