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ER-464195-01
CAS No. 859218-37-4
ER-464195-01( ER464195-01 )
Catalog No. M16228 CAS No. 859218-37-4
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameER-464195-01
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NoteResearch use only, not for human use.
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Brief DescriptionER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT).
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DescriptionER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5; dose-dependently and specificly inhibits GST-fused CRT proteins binding to ITGA4 in vitro pull-down assay; inhibits the PMA-induced T cells and the fMLP-stimulated neutrophils bound to VCAM1 (IC50=0.15 μM) and ICAM-1 (IC50=0.19 μM), respectively; suppresses the cell adhesion and the migration of leukocytes, prevents colitis and downregulates the expression of inflammation-related genes in DSS-treated mice, ameliorates the severity of disease in IBD mouse models.
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In Vitro——
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In Vivo——
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SynonymsER464195-01
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research Area——
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Indication——
Chemical Information
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CAS Number859218-37-4
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Formula Weight379.029
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Molecular FormulaC23H39ClN2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCN1CCN(CC1)C2=CC=CC=C2C3CC(CC(C3)(C)C)(C)C.Cl
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Chemical Name1-propyl-4-(2-(3,3,5,5-tetramethylcyclohexyl)phenyl)piperazine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Fibronectin CS1 Pept...
he connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. CS1 peptide of fibronectin, which lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models. The use of Fibronectin CS1 Peptide might offer a promising therapeutic approach for combating and preventing cancer metastasis.
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Abrilumab
Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin and can be used to study inflammatory bowel disease and ulcerative colitis.
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Vedolizumab
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
