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Dibucaine
CAS No. 85-79-0
Dibucaine( NSC 159055 )
Catalog No. M16224 CAS No. 85-79-0
Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 41 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDibucaine
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NoteResearch use only, not for human use.
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Brief DescriptionDibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.
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DescriptionDibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.(In Vitro):Dibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain. Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.
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In VitroDibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain.Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.
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In Vivo——
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SynonymsNSC 159055
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorAChR| CAM| Sodium Channel
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number85-79-0
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Formula Weight343.46
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Molecular FormulaC20H29N3O2
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Purity>98% (HPLC)
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SolubilityWater: 42 mg/L (at 21 °C)
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SMILESCCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC
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Chemical Name2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Oka M, et al. Eur J Pharmacol. 2002 Oct 4;452(2):175-8
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