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Home - Products - JAK/STAT Signaling - STAT - Indirubin E804

Indirubin E804

CAS No. 854171-35-0

Indirubin E804( E804 )

Catalog No. M16204 CAS No. 854171-35-0

An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
5MG 81 In Stock
10MG 126 In Stock
25MG 207 In Stock
50MG 302 In Stock
100MG 449 In Stock
200MG 643 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Indirubin E804
  • Note
    Research use only, not for human use.
  • Brief Description
    An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells.
  • Description
    An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro; decreases tyrosyl phosphorylation of Stat3, suppresses constitutive Stat3 DNA binding-activity in treated cells, also down-regulates antiapoptotic proteins Mcl-1 and Survivin; inhibits the subintestinal vessels formation in zebrafish embryos.
  • In Vitro
    Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM.
  • In Vivo
    ——
  • Synonyms
    E804
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    854171-35-0
  • Formula Weight
    365.389
  • Molecular Formula
    C20H19N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (342.11 mM)
  • SMILES
    C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=NOCCC(CO)O
  • Chemical Name
    3-[3-[(3,4-Dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nam S, et al. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003. 2. Zhou J, et al. Blood. 2009 Apr 23;113(17):4052-62. 3. Chan YK, et al. Biochem Pharmacol. 2012 Mar 1;83(5):598-607. 4. Nam S, et al. Mol Oncol. 2012 Jun;6(3):276-83.
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