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Trofinetide

CAS No. 853400-76-7

Trofinetide( NNZ 2566 )

Catalog No. M16197 CAS No. 853400-76-7

Trofinetide (NNZ 2566 ) is a peptidomimetic tripeptide Gly-Pro-Glu that has anti-inflammatory and neuroprotective properties against hypoxic-ischemic brain injury and neurodegeneration.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Trofinetide
  • Note
    Research use only, not for human use.
  • Brief Description
    Trofinetide (NNZ 2566 ) is a peptidomimetic tripeptide Gly-Pro-Glu that has anti-inflammatory and neuroprotective properties against hypoxic-ischemic brain injury and neurodegeneration.
  • Description
    Trofinetide (NNZ 2566 ) is a peptidomimetic tripeptide Gly-Pro-Glu that has anti-inflammatory and neuroprotective properties against hypoxic-ischemic brain injury and neurodegeneration; improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury; significantly reduces injury-mediated up-regulation of IL-1beta, TNF-alpha, E-selectin and IL-6 mRNA in the injured brain in rats.Other Indication Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NNZ 2566
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    853400-76-7
  • Formula Weight
    315.322
  • Molecular Formula
    C13H21N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : ≥ 50 mg/mL 158.57 mM
  • SMILES
    O=C(O)CC[C@@H](C(O)=O)NC([C@@]1(C)N(C(CN)=O)CCC1)=O
  • Chemical Name
    ((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bickerdike MJ, et al. J Neurol Sci. 2009 Mar 15;278(1-2):85-90. 2. Lu XC, et al. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32. 3. Wei HH, et al. J Neuroinflammation. 2009 Aug 5;6:19.
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