Enalaprilat Dihydrate( —— )

Catalog No. M16146 CAS No. 84680-54-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Enalaprilat Dihydrate
Note

Research use only, not for human use.
Brief Description

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
Description

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.(In Vitro):Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM.(In Vivo):Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.
In Vitro

Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM.
In Vivo

Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

RAAS
Recptor

ACE
Research Area

Cardiovascular Disease
Indication

——

CAS Number

84680-54-6
Formula Weight

348.4
Molecular Formula

C18H24N2O5.2H2O
Purity

>98% (HPLC)
Solubility

DMSO:70 mg/mL (200.91 mM)； Ethanol:<1 mg/mL (<1 mM)； Water:<1 mg/mL (<1 mM)
SMILES

O.O.C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |r,c:8,10,t:6|
Chemical Name

——

1.Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.

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