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Home - Products - JAK/STAT Signaling - STAT - Napabucasin

Napabucasin

CAS No. 83280-65-3

Napabucasin( BBI-608 )

Catalog No. M16087 CAS No. 83280-65-3

Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 65 In Stock
5MG 58 In Stock
10MG 81 In Stock
50MG 193 In Stock
100MG 343 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Napabucasin
  • Note
    Research use only, not for human use.
  • Brief Description
    Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
  • Description
    Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM); blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells; significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1); significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.Colon Cancer Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BBI-608
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT3
  • Research Area
    Cancer
  • Indication
    Colon Cancer

Chemical Information

  • CAS Number
    83280-65-3
  • Formula Weight
    240.2109
  • Molecular Formula
    C14H8O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3
  • Chemical Name
    Naphtho[2,3-b]furan-4,9-dione, 2-acetyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. 2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8. 3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.
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