Nefazodone hydrochloride( BMY 13754 | MJ13754-1 )

Catalog No. M16074 CAS No. 82752-99-6

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Product Name

Nefazodone hydrochloride
Note

Research use only, not for human use.
Brief Description

Nefazodone hydrochloride is an antidepressant drug.
Description

Nefazodone hydrochloride is an antidepressant drug.(In Vitro):Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.
In Vitro

Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.
In Vivo

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Synonyms

BMY 13754 | MJ13754-1
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT
Research Area

Neurological Disease
Indication

——

CAS Number

82752-99-6
Formula Weight

506.47
Molecular Formula

C25H33Cl2N5O2
Purity

>98% (HPLC)
Solubility

DMSO: ~11?mg/mL at?60?°C
SMILES

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.[H]Cl
Chemical Name

2-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride

1.Bengi Uslu, et al. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57

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