Fluticasone propionate( Fluticasone 17-Propionate )

Catalog No. M16013 CAS No. 80474-14-2

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Product Name

Fluticasone propionate
Note

Research use only, not for human use.
Brief Description

Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
Description

Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.(In Vitro):Fluticasone propionate inhibits TNFα-induced E-selectin expression, with an IC50 of 1 nM.
In Vitro

——
In Vivo

——
Synonyms

Fluticasone 17-Propionate
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

ER| Mineralocorticoid Receptor| Glucocorticoid Receptor| Cytosolic PLA2
Research Area

Inflammation/Immunology
Indication

——

CAS Number

80474-14-2
Formula Weight

500.57
Molecular Formula

C25H31F3O5S
Purity

>98% (HPLC)
Solubility

Ethanol: 5 mg/mL (9.98 mM); DMSO: 100 mg/mL (199.77 mM)
SMILES

CCC(O[C@]1(C(SCF)=O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@@]3(F)[C@H]2C[C@H](F)C4=CC(C=C[C@@]43C)=O)=O
Chemical Name

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

1.Andersson O, et al. J Allergy Clin Immunol. 1999 Apr;103(4):595-600.

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