Hippuristanol( Hippuristanol )

Catalog No. M16010 CAS No. 80442-78-0

Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Hippuristanol
Note

Research use only, not for human use.
Brief Description

Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A).
Description

Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A), results in cell cycle arrest at G1 phase, and induces caspases activation and apoptosis; also reduces the expression of cyclin D2, CDK2, CDK4, CDK6 and prosurvival XIAP and Mcl-1 proteins; significantly inhibits the growth and invasion of PEL cells in mice.
In Vitro

——
In Vivo

——
Synonyms

Hippuristanol
Pathway

Nuclear Receptor/Transcription Factor
Target

eIF
Recptor

eIF
Research Area

——
Indication

——

Chemical Information

CAS Number

80442-78-0
Formula Weight

462.66
Molecular Formula

C28H46O5
Purity

>98% (HPLC)
Solubility

——
SMILES

[H][C@]1(O[C@@](C[C@H](C)C2(C)C)(O2)[C@@]3(O)C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@H](O)CC[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]13[H]
Chemical Name

(3R,5S,11S,20R,22S,24S)-24-Methyl-22,25-epoxyfurostan-3,11,20-triol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Cencic R, et al. Translation (Austin). 2016 Jan 4;4(1):e1137381. 2. Somaiah R, et al. J Med Chem. 2014 Mar 27;57(6):2511-23. 3. Ishikawa C, et al. Mar Drugs. 2013 Sep 6;11(9):3410-24.

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