Azelastine hydrochloride

Research use only, not for human use.

Azelastine HCl is a potent, second-generation, selective, histamine antagonist.

Azelastine HCl is a potent, second-generation, selective, histamine antagonist.(In Vitro):Azelastine hydrochloride can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling.(In Vivo):Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model.

Azelastine hydrochloride can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling. Cell Proliferation AssayCell Line:Human nasal epithelial cells (HNEpC)Concentration:100 μM, 400 μM Incubation Time:21 days Result:Inhibited HNEpC growth.Western Blot Analysis Cell Line:Human nasal epithelial cells (HNEpC) Concentration:100 μM Incubation Time:7 days Result:Significantly up-regulated the H1R, M1R and M3R levels.

Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model. Animal Model:Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats model Dosage:4 mg/kg Administration: Oral administration, daily, for 8 weeks Result:Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.

Azelastine HCl | Astelin | Optivar | Allergodil | Rhinolast | Azeptin

GPCR/G Protein

Histamine Receptor

H1 receptor

Inflammation/Immunology

——

79307-93-0

418.36

C22H24ClN3O·HCl

>98% (HPLC)

Ethanol: 84 mg/mL (200.78 mM); Water: 35 mg/mL (83.66 mM); DMSO: 84 mg/mL (200.78 mM)

CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years