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Citric acid
CAS No. 77-92-9
Citric acid ( —— )
Catalog No. M15941 CAS No. 77-92-9
Citric acid is a weak organic tricarboxylic acid found in citrus fruits.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 35 | In Stock |
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| 1G | 50 | In Stock |
|
Biological Information
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Product NameCitric acid
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NoteResearch use only, not for human use.
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Brief DescriptionCitric acid is a weak organic tricarboxylic acid found in citrus fruits.
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DescriptionCitric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer. (In Vitro):Citric acid (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.Citric acid (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Citric acid (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl.(In Vivo):Citric acid (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver.Citric acid (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.Citric acid (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice.
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In VitroCitric acid (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.?Citric acid (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Citric acid (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl. Cell Viability Assay Cell Line:HaCaT cells Concentration:0, 2.5, 5, 7.5, 10, 12.5 mM Incubation Time:24 h Result:Inhibited the cell viability in a dose dependent manner.Cell Cytotoxicity Assay Cell Line:HaCaT cells Concentration:12.5 mM Incubation Time:0, 12, 24, 48, 72 h Result:Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Western Blot Analysis Cell Line:HaCaT cells Concentration:12.5 mM Incubation Time:12, 24, 48 h Result:Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
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In VivoCitric acid (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver. Citric acid (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.Citric acid (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice. Animal Model:20 g male Kunming mice Dosage:120, 240, 480 mg/kg Administration:I.p.; weekly for 3 weeks Result:T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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Recptor——
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number77-92-9
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Formula Weight192.12
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Molecular FormulaC6H8O7
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Purity>98% (HPLC)
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SolubilityN/A
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SMILESOC(CC(CC(O)=O)(C(O)=O)O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20.
2. Abdel-Salam OM, et al. Citric acid effects on brain and liver oxidative stress in lipopolysaccharide-treated mice. J Med Food. 2014 May;17(5):588-98.
3. Lacour B, et al. Stimulation by citric acid of calcium and phosphorus bioavailability in rats fed a calcium-rich diet. Miner Electrolyte Metab. 1997;23(2):79-87.
4. nagai R, et al. Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats. Biochem Biophys Res Commun. 2010 Feb 26;393(1):118-22.
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