ML406( ML406 | ML-406 | ML 406 )

Catalog No. M15926 CAS No. 774589-47-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML406
Note

Research use only, not for human use.
Brief Description

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity.
Description

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD; exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.
In Vitro

ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB).
In Vivo

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Synonyms

ML406 | ML-406 | ML 406
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

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CAS Number

774589-47-8
Formula Weight

352.39
Molecular Formula

C20H20N2O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (283.78 mM)
SMILES

CC(C1=CC=C(N2CCN(C(C3=CC=C(OCO4)C4=C3)=O)CC2)C=C1)=O
Chemical Name

1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone

1. Casalena D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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