4-Methylpyrazole

Research use only, not for human use.

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. (In Vivo):Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice.

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Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice Animal Model:Male CD-1 mice weighing 18-25 gDosage:25 mg/kg Administration:IP; single dose Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).

4-Methylpyrazole

Endocrinology/Hormones

AChR

ADH| CAT

Other Indications

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7554-65-6

82.1

C4H6N2

>98% (HPLC)

Water: 146 mg/mL

CC1=CNN=C1

4-methyl-1H-pyrazole

(-20℃)

With Ice Pack

≥ 2 years